Nuchal translucency and first trimester biochemical markers for Down syndrome screening: a cost-effectiveness analysis

Nuchal translucency and first trimester biochemical markers for down syndrome screening: a cost-effectiveness analysis.

OBJECTIVE The purpose of this study was to perform a cost-effectiveness analysis that compared the first- and second- trimester screening tools for Down syndrome. STUDY DESIGN A decision tree was designed that compared four possible screens for Down syndrome: (1) current second- trimester expanded maternal serum alpha-fetoprotein test (AFP), (2) first-trimester nuchal translucency screen, (3)...

Nuchal translucency and first trimester biochemical markers for Down syndrome screening: a cost-effectiveness analysis

Nuchal translucency and first trimester biochemical markers for Down syndrome screening: a cost-effectiveness analysis

Nuchal translucency and first trimester biochemical markers for Down syndrome screening: a cost-effectiveness analysis

A cost-effectiveness analysis of prenatal screening strategies for Down syndrome.

OBJECTIVE To evaluate which Down syndrome screening strategy is the most cost-effective. METHODS Using decision-analysis modeling, we compared the cost-effectiveness of 9 screening strategies for Down syndrome: 1) no screening, 2) first-trimester nuchal translucency (NT) only, 3) first-trimester combined NT and serum screen, 4) first-trimester serum only, 5) quadruple screen, 6) integrated sc...